Combined Dexmedetomidine and Glycopyrrolate Therapy

Combined Dexmedetomidine and Glycopyrrolate Therapy for Prevention of Catheter Related Bladder Discomfort After Transurethral Bladder Surgery

Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation. The mechanism of the catheter-related bladder discomfort is similar to that of overactive bladder, in which muscarinic acetylcholine receptors are stimulated. The catheter-related bladder discomfort is a well known predisposing factor for emergence delirium after general anesthesia. In this study, we aimed to compare the incidence of catheter-related bladder discomfort between dexmedetomidine only therapy and combind dexmedetomidine and glycopyrrolate therapy.

Inclusion Criteria:

• American Society of Anesthesiologists physical status I and II
• elective transurethral resection of bladder tumor under general anesthesia

Exclusion Criteria:

• arrhythmia
• bladder outflow obstruction
• overacitve bladder
• end stage renal disease
• neurogenic bladder
• morbid obesity
• psychiatric disorder