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| Name | Class |
|---|---|
| Benha University | OTHER |
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The insertion of a urinary catheter in a patient undergoing a surgical procedure, especially urinary interventions, may lead to catheter-related bladder discomfort (CRBD) with varying degrees of severity during the postoperative period. Paracetamol is a drug with proven efficacy for the management of mild and moderate postoperative pain. Tramadol is a centrally acting, synthetic opioid analgesic with weak opioid agonist properties. It inhibits the detrusor activity by inhibition of type-1 muscarinic (M1) and type-3 muscarinic (M3) receptors. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, with analgesic, sedative, anxiolysis, sympatholytic, and sedative properties, is a very useful associated agent for general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DP group | Active Comparator | Group I (DP group) will receive dexmedetomidine 0.5 mic/kg and paracetamol 10mg/kg |
|
| TP group | Active Comparator | Group II (TP group) will receive tramadol 1mg/kg and paracetamol 10mg/kg. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine 0.5 mic/kg | Drug | Group I (DP group) will receive dexmedetomidine 0.5 mic/kg and paracetamol 10mg/kg, |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of catheter-related bladder discomfort (CRBD) | The incidence of catheter-related bladder discomfort (CRBD) will be assessed at 30 minutes and 1, 2, 4, 6,8,10,12 and 24 hours postoperatively. | 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain | Postoperative pain will be assessed with the Visual Analog Scale (VAS) (0, no discomfort and no pain; 10, a high level of discomfort and maximum pain) | 24 hours postoperatively |
| Meperidine requirement |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neveen Kohaf | Recruiting | Cairo | Cairo Governorate | 11865 | Egypt |
Data will be available upon reasonable request from corresponding author
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| ID | Term |
|---|---|
| D014147 | Tramadol |
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 |
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| Tramadol 1mg/kg | Drug | Group II (TP group) will receive tramadol 1mg/kg and paracetamol 10mg/kg. |
|
| Paracetamol 10mg/kg | Drug | Group I (DP group) will receive dexmedetomidine 0.5 mic/kg and paracetamol 10mg/kg. Group II (TP group) will receive tramadol 1mg/kg and paracetamol 10mg/kg. |
|
Total amount of consumed meperidine will be documented
| 24 hours postoperatively |
| Patient satisfaction | Patients' satisfaction was measured immediately postoperative and after 24 hours using a five-point Likert scale consisting of "very dissatisfied," "dissatisfied," "unsure," "satisfied," and "very satisfied. | 24 hours postoperatively |
| Surgeon satisfaction | Surgeon' satisfaction was measured immediately postoperative and after 24 hours using a five-point Likert scale consisting of "very dissatisfied," "dissatisfied," "unsure," "satisfied," and "very satisfied. | 24 hours postoperatively |
| Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D000814 | Aniline Compounds |