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The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration.
A secondary aims: exploring the effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status, and measurement of changes in the skin nicotinamide-adenine dinucleotide reduced form (NADH) content during transient ischemia and reperfusion.
In a random order subjects will consume beetroot juice (140ml), or equimolar nitrates (NaNO3). Antecubital vein blood samples will be taken at the beginning, and every hour for 4 hours following consumption.
Plasma trimethylamine N-oxide, total antioxidant status, and nitrite/nitrate concentrations will be determined.
Using Flow Mediated Skin Fluorescence skin NADH content determined during controlled ischemia triggered by total occlusion of the brachial artery by the brachial blood pressure cuff and during reperfusion after deflation of the blood pressure cuff 2 and 4 hours following consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| beetroot juice | Experimental | single intake of beetroot juice containing 800mg nitrates |
|
| nitrates | Active Comparator | single intake of 800mg nitrates (NaNO3) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| beetroot juice | Dietary Supplement | single intake of beetroot juice containing 800mg nitrates |
|
| Measure | Description | Time Frame |
|---|---|---|
| The effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration | Determination of plasma trimethylamine N-oxide concentration following the beetroot juice consumption using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method. | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status | Determination of plasma total antioxidant status following the beetroot juice consumption using commercially available kit. | 4 hours |
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Inclusion Criteria:
healthy volunteers
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert A Olek, PhD | Poznan University of Physical Education | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akademia Wychowania Fizycznego | Poznan | 61-871 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38110180 | Derived | Jurga J, Samborowska E, Zielinski J, Olek RA. Effects of Acute Beetroot Juice and Sodium Nitrate on Selected Blood Metabolites and Response to Transient Ischemia: A Crossover Randomized Clinical Trial. J Nutr. 2024 Feb;154(2):491-497. doi: 10.1016/j.tjnut.2023.12.018. Epub 2023 Dec 16. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 5, 2024 | |
| Reset | Dec 13, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 5, 2024 | Dec 13, 2024 |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D009566 | Nitrates |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D017942 |
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| nitrate | Other | single intake of 800mg nitrates |
|
|
| Nitric Acid |
| D017672 | Nitrogen Compounds |
| D009930 | Organic Chemicals |