NYSPI-wide Institutional Research Pause as of June 12, 2023.

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning. This study will also examine the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life, drug use). The training component of the study lasts 1 month, with follow up visits and 1-month and 3-months post training.

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose (i.e. overdose that does not result in death), cognitive functioning, and the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life). Participants (n=30) with a history of at least one prior opioid OD, who are enrolled in buprenorphine treatment, will be randomized to 20 sessions of an active (n=15) or sham (n=15) working memory training. Patients will complete measures of cognitive functioning during screening, post-training, and at 1-month and 3-month follow up. Participants will also complete the measures of decision making, psychosocial functioning and drug use at baseline, post-training, and follow up.

Inclusion Criteria:

• Meets DSM-5 criteria for moderate-severe Opioid Use Disorder (OUD) in the past 6 months
• Enrolled in a suboxone (buprenorphine/naloxone) program; willing to provide consent for research team to contact treatment provider
• History of at least 1 prior opioid overdose
• Recent history of illicit opioid use
• In good physical health
• Access to a smartphone, tablet, or computer

Exclusion Criteria:

• Evidence of a co-occurring, untreated psychiatric condition that would make participation risky or difficulty
• Lack of access to a home computer, smartphone, or tablet
• Unable to speak, read and/or communicate in English

Participants and research staff will be blinded to participant's training condition (active vs. sham)