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Study halted due to Covid-19 precautions
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Research has consistently found that cognitive impairment is common in persons with a history of substance abuse. The most commonly identified impairments across all substances are in attentional and working memory functioning and executive functioning; opioid-specific research finds that memory is an additional area of common impairment. Initial research in applying cognitive rehabilitation methods to substance abuse have shown it to be helpful overall.
To develop a cognitive rehabilitation intervention that is effective for opioid abuse, this study will adapt a cognitive training program that has been shown to be effective in other patient groups. Patients in a residential opioid-abuse treatment program will undergo a cognitive evaluation and then be assigned to receive the 4-week cognitive intervention or the 4-week placebo control arm. It is expected that the intervention group will show greater gains on the cognitive post test and will have higher rated treatment adherence and opioid treatment program completion rates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Three times per week for four weeks, participants will complete a computerized cognitive training session (approximately 30 minutes long). |
|
| Control | Placebo Comparator | Three times per week for four weeks, participants will complete a computerized session (approximately 30 minutes long) that consists of inert computer games. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Training | Behavioral | Exercises used will be: Mind Bender, Divided Attention, Freeze Frame, Mixed Signals, Target Tracker, To Do List. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean Cognitive Change from Baseline to Endpoint | Change in overall cognitive summary score from pretest to posttest on NIH Toolbox. | Post-intervention at week 4 |
| Substance Abuse Program Completion Rate | Completion rate of recommended treatment program length, quantified as percentage completed | Until treatment program discharge, usually 30-45 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alicia Ford, PhD | Oklahoma State University Center for Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 12&12, Inc | Tulsa | Oklahoma | 74135 | United States |
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Placebo Control | Behavioral | Games are drawn from the set of research control games provided by Posit Science-Brain HQ. |
|
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |