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The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger & satiety.
The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sucrose | Experimental | 10% solution in water |
|
| Sucrose + Reb M | Experimental | 10% sucrose + 60 mg/L Rebaudioside M |
|
| Sucrose + Lactisole | Experimental | 10% sucrose + 30 mg/ L Lactisole |
|
| Sucrose + Reb M + Lactisole | Experimental | 10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactisole | Drug | sweet taste inhibitor (decreases sweetness) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose concentration | Glucose concentration [mg/dL] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution | over a time span of 120 minutes after drinking the test solution |
| Insulin concentration | Insulin concentration [mmol/L] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution | over a time span of 120 minutes after drinking the test solution |
| GLP-1 concentration | Glucagon-like peptide 1 concentration in plasma samples [mmol/L] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution | over a time span of 120 minutes after drinking the test solution |
| GIP-concentration | Gastric inhibitory polypeptide concentration in plasma samples [mmol/L] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution | over a time span of 120 minutes after drinking the test solution |
| Measure | Description | Time Frame |
|---|---|---|
| Food intake | Ad libitum Food intake from a standardized breakfast | 120 minutes after drinking of the test solution |
| Metabolic changes | Metabolome analysis in plasma samples [mmol/L] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Barbara Lieder, PhD | University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Christian Doppler Laboratory for Taste Research | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| C495512 | lactisole |
| C000590692 | rebaudioside M |
| D013395 | Sucrose |
| D019422 | Dietary Sucrose |
| ID | Term |
|---|---|
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| Rebaudioside M | Drug | Sweetener (increases sweetness) |
|
|
| Sucrose | Other | 10% Sucrose corresponding to a regular soft drink |
|
|
| over a time span of 120 minutes after drinking the test solution |
| D000073893 |
| Sugars |
| D000073417 | Dietary Sugars |
| D004040 | Dietary Carbohydrates |
| D064427 | Nutritive Sweeteners |
| D013549 | Sweetening Agents |
| D005421 | Flavoring Agents |
| D005503 | Food Additives |
| D000074385 | Food Ingredients |
| D020313 | Specialty Uses of Chemicals |
| D020164 | Chemical Actions and Uses |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |