Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism
The study is designed as a randomised cross-over intervention study with three arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, and a less sweet 7% sucrose solution w/o hesperetin on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers.
To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10% Sucrose | Experimental | 10% (w/v) sucrose in water |
|
| Sucrose + Hesperetin | Experimental | 7% (w/v) sucrose in water + 50 mg/L Hesperetin |
|
| 7% sucrose | Experimental | 7% (w/v) sucrose in water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 10% Sucrose | Other | 10% sucrose corresponding to a regular soft drink |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood glucose concentration | Change compared to baseline in blood glucose concentration [mg/dL] in plasma samples after drinking the test solution | 15, 30, 60, 90, and 120 minutes after drinking the test solution |
| Change in appetite score | Change compared to baseline in the subjective rating of the individual feeling of hunger, fullness, as well as appetite for a snack or for something sweet on a unstructured, digital visual analog scale ranging from 0-10 cm in comparison to baseline | Difference between before and 120 minutes after drinking of the test solution |
| Change in food intake | Ad libitum food intake from a standardized breakfast | 120 minutes after drinking of the test solution |
| Measure | Description | Time Frame |
|---|---|---|
| Change in regulating hormones | Change compared to baseline in Insulin, Glucagon-like peptide 1, Gastric inhibitory polypeptide, and Polypetide Y concentrations [mmol/L] in plasma samples after drinking the test solution | 15, 30, 60, 90, and 120 minutes after drinking the test solution |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Barbara Lieder, PhD | University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Christian Doppler Laboratory for Taste Research | Vienna | State of Vienna | 1090 | Austria |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013395 | Sucrose |
| D019422 | Dietary Sucrose |
| ID | Term |
|---|---|
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Sucrose+ Hesperetin | Drug | Addition of hesperetin increases sweetness of 7% sucrose solution to match sweetness of 10% sucrose solution |
|
|
| 7% Sucrose | Other | 7% sucrose to match the caloric content of the sugar-reduced hesperetin intervention |
|
|
| D000073893 |
| Sugars |
| D000073417 | Dietary Sugars |
| D004040 | Dietary Carbohydrates |
| D064427 | Nutritive Sweeteners |
| D013549 | Sweetening Agents |
| D005421 | Flavoring Agents |
| D005503 | Food Additives |
| D000074385 | Food Ingredients |
| D020313 | Specialty Uses of Chemicals |
| D020164 | Chemical Actions and Uses |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |