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| Name | Class |
|---|---|
| Iovate Health Sciences International Inc | INDUSTRY |
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An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive. Amino acids are the building blocks of protein, and when consumed following resistance exercise, significantly improve NPB.
However, no study has investigated how a supplement of all of the essential amino acids (EAA) affects NPB following resistance exercise in a free-living, home-based setting, particularly when compared to a supplement of branched-chain amino acids (BCAA).
Therefore, the purpose of this study is to determine the impact of a novel EAA supplement on anabolism (e.g., NPB) as compared to BCAA and placebo supplements following home-based resistance exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Novel essential amino acid supplementation (EAA+) | Experimental | Arm will investigate the effect of a novel essential amino acid-based formula (essential amino acids enriched with active botanical compounds; EAA+) developed by Iovate Health Sciences International Inc. on post-exercise anabolism. The formulation was recently granted a Natural Product Number (NPN: 80087022) and approved by the Natural and Non-prescription Health Products Directorate of Health Canada. |
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| Branched-chain amino acid supplementation (BCAA) | Active Comparator | Arm will used a branched-chain amino acid supplement developed by Iovate Health Sciences International Inc. to compare with the experimental arm after exercise. |
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| Isocaloric carbohydrate supplementation | Placebo Comparator | Carbohydrate supplement that is isocaloric to the EAA+ supplement and designed to function as a placebo to the experimental arm after exercise. |
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| Rested control | Other | Carbohydrate supplement that is isocaloric to the EAA+ supplement but consumed at rest to serve as the baseline control |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Novel essential amino acid supplementation | Dietary Supplement | This intervention will determine the impact of EAA+ on markers of whole-body net protein balance, protein synthesis, and protein breakdown following home-based resistance exercise in a free-living setting. |
| Measure | Description | Time Frame |
|---|---|---|
| Whole-body net leucine balance (umol/kg) | Used as a proxy of whole-body protein balance, and estimated by using [13C]leucine ingestion and breath/urine sample collection | 5 hours/trial (four trials total) |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary 3-methylhistidine (3-methylhistidine:creatinine ratio) | Used as a marker of muscle protein breakdown by measuring the 3-methylhistidine:creatinine ratio in the urine | 5 hours/trial (four trials total) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Moore | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goldring Centre for High Performance Sport | Toronto | Ontario | M5S2C9 | Canada |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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In a randomized, counterbalanced order, participants will receive all treatments arms (essential amino acids, branched-chain amino acids, and placebo).
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All investigators involved with the study, as well as participants, will be blinded to treatment conditions (double-blind design) until data analysis is completed.
| Branched-chain amino acid supplementation (BCAA) | Dietary Supplement | This intervention will determine the impact of the BCAA supplement (to be compared to EAA+) on markers of whole-body net protein balance, protein synthesis, and protein breakdown following home-based resistance exercise in a free-living setting. |
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| Isocaloric carbohydrate supplementation | Dietary Supplement | This intervention will determine the impact of an isocaloric carbohydrate placebo supplement (to be compared to EAA+) on markers of whole-body net protein balance, protein synthesis, and protein breakdown following home-based resistance exercise in a free-living setting. |
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