Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery

Opioid Sparing Anaesthesia Via Dexmedetomidine, Ketamine and Lidocaine Infusion for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery

In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and vomiting (PONV) are still common complaints reported after laparoscopic gynecological surgery.

So, it is hypothesized that the infusion consisting of lidocaine, dexmedetomidine and ketamine, as an opioid substitute was a feasible technique for laparoscopic gynecological surgery and would be associated with less incidence of PONV and lower opioid requirements in the early postoperative period.

The aim of this study was to evaluate the effect of opioid sparing technique via infusion of Dexmedetomidine, Ketamine and Lidocaine on post-operative nausea and vomiting in laparoscopic gynecological surgery.

Inclusion Criteria:

• Patients scheduled for elective laparoscopic gynaecological surgery, who:

  • had the American Society of Anesthesiologists (ASA) I or II physical status,
  • were 21-60 years of age

Exclusion Criteria:

• A body mass index >35 kg/ m2
• Pregnant, breast feeding women
• Hepatic, renal or cardiac insufficiency
• Diabetes mellitus
• History of chronic pain
• Alcohol or drug abuse
• Psychiatric disease
• Allergy or contraindication to any of the study drugs