Post-operative nausea and vomiting (PONV) is common for the patients undergoing laparoscopic gynecologic surgery. PONV is a major factor for patient dissatisfaction, delayed patient recovery and increased medical expenses. Opioid-reducing anesthetic regimen is known to decrease PONV and facilitate early recovery after surgery (ERAS) and has been widely accepted recently. In this study, the researchers intend to investigate whether opioid-free anesthesia effectively reduces PONV, and whether it is clinically safe and feasible.

Inclusion Criteria:

• Patients scheduled for laparoscopic gynecologic surgery (≥90 min) for benign or malignant uterine/ovarian disease
• Age ≥ 19
• ASA (American Society of Anesthesiologists) class I-II

Exclusion Criteria:

• Uncontrolled hypertension
• Untreated intracranial aneurysm
• Severely impaired renal or hepatic function
• Pregnancy
• History of hypersensitivity for drugs used in the study
• Patients not using NSAID-containing IV PCA (patient controlled analgesia) device post-operatively