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BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy.
METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine (0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON group, n=60) received the equal volume of saline. Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Effect of IV lidocaine and dexmedetomidine on PONV | Experimental |
| |
| Effect of IV saline on PONV | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lidocaine and dexmedetomidine IV | Drug | Patients received IV bolus infusion of lidocaine (2%) 1.5 mg/kg and dexmedetomidine 0.5 µg/kg diluted with normal saline to 20 ml in the LD group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion at rate of lidocaine 1.5 mg/kg and dexmedetomidine 0.4 µg/kg made up to 20 mL every hour until 30 min before the end of operation, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative nausea | Our primary outcome was the incidence of nausea during the 0-2 hours after surgery | 0-2 hours after surgery |
| postoperative nausea | Our primary outcome was the incidence of nausea during the 2-24 hours after surgery | 2-24 hours after surgery |
| postoperative nausea | Our primary outcome was the incidence of nausea during the 24-48 hours after surgery | 24-48 hours after surgery |
| postoperative vomiting | Our primary outcome was the incidence of vomiting during the 0-2 hours after surgery | 0-2 hours after surgery |
| postoperative vomiting | Our primary outcome was the incidence of vomiting during the 2-24 hours after surgery | 2-24 hours after surgery |
| postoperative vomiting | Our primary outcome was the incidence of vomiting during the 24-48 hours after surgery | 24-48 hours after surgery |
| postoperative nausea and vomiting (PONV) | Our primary outcome was the incidence of PONV during the 0-2 hours after surgery | 0-2 hours after surgery |
| postoperative nausea and vomiting (PONV) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anqing Hospital Anesthesiology | Anqing | Anhui | 246000 | China |
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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|
| saline IV | Drug | Patients received 20 ml normal saline and 20 ml normal saline in the CON group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion 20 ml normal saline and 20 ml normal saline every hour until 30 min before the end of surgery |
|
Our primary outcome was the incidence of PONV during the 2-24 hours after surgery |
| 2-24 hours after surgery |
| postoperative nausea and vomiting (PONV) | Our primary outcome was the incidence of PONV during the 24-48 hours after surgery | 24-48 hours after surgery |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |
| Aniline Compounds |
| D000588 | Amines |