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BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine might improve the quality of recovery undergoing laparoscopic surgery. The investigators investigated whether co-administration lidocaine and dexmedetomidine could better improve the the quality of recovery after laparoscopic total hysterectomy.
METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close the pneumoperitoneum, respectively. Patients in group C received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days after sugery. The secondary outcomes included perioperative remifentanil consumption, postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale at 5 min, 10min, 30 min, 60 min after extubation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery | Experimental |
| |
| Effect of Dexmedetomidine infusion on Quality of Recovery | Experimental |
| |
| Effect of Lidocaine infusion on Quality of Recovery | Experimental |
| |
| Effect of saline infusion on Quality of Recovery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Co-administration Lidocaine and Dexmedetomidine | Drug | Patients received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close of the pneumoperitoneum, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of recovery scores(QoR-40) | Our primary outcome was Quality of recovery scores(QoR-40) 1 day after operation | 1 day after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative remifentanil total dose | Secondary Outcome Measure was remifentanil total dose during the perioperative period | Intraoperative |
| Recovery time | Secondary Outcome Measure was recovery time |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anqing Hospital Anesthesiology | Anqing | Anhui | 246000 | China |
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| Dexmedetomidine infusion | Drug | Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close of the pneumoperitoneum. |
|
| Lidocaine infusion | Drug | Patients received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close of the pneumoperitoneum. |
|
| Saline infusion | Drug | Patients received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close of the pneumoperitoneum. |
|
| Immediately after the surgery |
| Extubation time | Secondary Outcome Measure was extubation time | Immediately after the surgery |
| Pain visual analogue scale scores | Secondary Outcome Measure was pain visual analogue scale scores | The first 24 hours after operation |
| PONV scores | Secondary Outcome Measure was PONV scores | The first 24 hours after operation |
| The consumption of sufentanil | Secondary Outcome Measure was consumption of sufentanil | The first 24 hours after operation |
| The length of post-anesthesiacare unit stay | Secondary Outcome Measure was the length of post-anesthesiacare unit stay | Immediately after the surgery |
| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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