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| Name | Class |
|---|---|
| Pfizer | INDUSTRY |
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Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data. The epidemiology of bacterialméningitis has changed in recent years, mainly owing to widespread use of different conjugate vaccines. The aim of this prospective national survey is to describe epidemiology of bacteria implicated in bacterial meningitis in children.
For children under 18, hospitalized for bacterial meningitis, the following data will be analyzed: risk factors, vaccination status, signs of symptoms, treatment during hospitalization, analysis (cerebrospinal fluid culture, cerebrospinal fluid antigen test, blood culture...), symptoms or clinic signs of illness.
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| Measure | Description | Time Frame |
|---|---|---|
| mortality | Number of death according to age and bacteria | before the hospital discharge |
| Measure | Description | Time Frame |
|---|---|---|
| treatment failures | Number of antibiotic treatment failures according to bacteria after the control of lumbar puncture | 48 hours after the antibiotic treatment and new lumbar puncture |
| impact of vaccines |
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Inclusion Criteria:
Exclusion Criteria:
-
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children 0 day to 18 years with bacterial meningitis or purpura fulminans
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Corinne Levy, MD | Contact | 0033148850404 | corinne.levy@activ-france.fr | |
| Stephane Bechet | Contact | 1 48 85 96 68 | +33 | stephane.bechet@activ-france.fr |
| Name | Affiliation | Role |
|---|---|---|
| Corinne Levy, MD | Association Clinique Thérapeutique Infantile du val de Marne | Study Director |
| Robert Cohen | Association Clinique Thérapeutique Infantile du val de Marne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ACTIV | Recruiting | Créteil | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40924727 | Derived | Maunier L, Levy C, Baron A, Weill FX, Bechet S, Pardos de la Gandara M, Caseris M, Abdoul C, Dommergues MA, Cohen R, Bonacorsi S. Retrospective Description of 27 Cases of Nontyphoidal Salmonella Meningitis in Pediatrics Over 22 Years in France Pleads for a Revision of Age Limit for the Treatment of Salmonella Gastroenteritis in Children. Pediatr Infect Dis J. 2026 Jan 1;45(1):e10-e12. doi: 10.1097/INF.0000000000004966. Epub 2025 Sep 3. | |
| 40063777 |
| Label | URL |
|---|---|
| Recurrent Pneumococcal Meningitis in Children: A Multicenter Case-control Study | View source |
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| ID | Term |
|---|---|
| D008581 | Meningitis |
| ID | Term |
|---|---|
| D000090862 | Neuroinflammatory Diseases |
| D009422 | Nervous System Diseases |
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Number of vaccination failures according to age, number of doses and bacteria
| before the hospital discharge |
| Derived |
| Fafi I, Cohen R, Levy C, Varon E, Amor-Chelihi L, Benhaim P, Houlier M, Koehl B, De Montalembert M, Allali S, Gauthier A, Odievre MH, Gajdos V, Escoda S, Kamdem A, Costa G, Guillaumat C, Thuret I, Ouldali N, Gaschignard J, Carbonnelle E, De Pontual L, Pham LL. High Mortality Due to Pneumococcal Meningitis in Children With Sickle Cell Disease: A French Multicenter Observational Study From 2001 to 2021. Pediatr Infect Dis J. 2025 Jun 1;44(6):496-502. doi: 10.1097/INF.0000000000004755. Epub 2025 Mar 7. |
| 38108805 | Derived | Rybak A, Ouldali N, Varon E, Taha MK, Bonacorsi S, Bechet S, Angoulvant F, Cohen R, Levy C; French Pediatric Meningitis Network. Vaccine-preventable Pediatric Acute Bacterial Meningitis in France: A Time Series Analysis of a 19-Year Prospective National Surveillance Network. Pediatr Infect Dis J. 2024 Jan 1;43(1):74-83. doi: 10.1097/INF.0000000000004134. Epub 2023 Nov 13. |
| Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey | View source |
| Clinical and Laboratory Features of Group B Streptococcus Meningitis in Infants and Newborns: Study of 848 Cases in France, 2001-2014 | View source |
| Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network | View source |
| Neonatal Meningococcal Meningitis In France From 2001 To 2013 | View source |
| Comparative impact of pneumococcal conjugate vaccines on pneumococcal meningitis according to underlying conditions | View source |
| Outcomes of bacterial meningitis in children | View source |
| Vaccine-preventable Pediatric Acute Bacterial Meningitis in France: A Time Series Analysis of a 19-Year Prospective National Surveillance Network | View source |
| Increase of Haemophilus influenzae type b meningitis, beyond initial findings | View source |
| Adjunctive dexamethasone and 30-day all-cause death after hospital admission in paediatric pneumococcal meningitis: a propensity score analysis | View source |
| High Mortality Due to Pneumococcal Meningitis in Children With Sickle Cell Disease: A French Multicenter Observational Study From 2001 to 2021 | View source |