National, Non Interventional Study of Invasive Pneumococcal Disease in Children and Newborns

Population-based Nationwide Study on Invasive Pneumococcal Infections Among Children (0-18 Years) in France

After 7 then 13 valent pneumococcal conjugate vaccine (PCV) implementation in France in children, we will evaluate the impact of this vaccination on invasive pneumococcal disease (IPD). We will describe the clinical characteristics of IPD, pneumococcus serotyping, underlying conditions and vaccination status.

For children under 18, hospitalized for IPD, the following data will be analyzed: risk factors, vaccination status, severity signs , treatment during hospitalization, biological analysis, the clinical location of the disease.

Inclusion Criteria:

• Isolate of Streptococcus pneumoniae from at least one blood culture, or pleural fluid, or joint fluid, or cerebrospinal fluid or other normally sterile body site, or if there is a positive blood polymerase chain reaction (PCR).

Exclusion Criteria:

• Pneumococcal strain not transmetted to National Reference Center for Pneumococci or to Regional Pneumococci Observatory