Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 in Patients Having to be Vaccinated MenBVac® (Extension EFFIVAC)

Phase 3, Vaccinal Activity Assessment of MenBVac Against Neisseria Meningitidis B:14,P1.7,16 Strain in Child

The main objective of the study is to estimate the proportion of children, born between the 06/04/2004 and the 17/004/2008, living around Neufchatel en Bray, vaccinated by MenBVac, with a serum bactericidal activity against B:14,P1-7,16 clone related to a protection (>= 4), before the fourth dose of MenBvac and after: 6 weeks and one year after the fourth dose.

Inclusion Criteria:

• children born between 06/04/2004 and 17/04/2008, living in Neufchatel en Bray,and Having participated to the first study,
• children who Have to be Vaccinated MenBVac® for the four times,
• parental authority(ies)assent.

Exclusion Criteria:

• no parental authority(ies)assent,
• no blood sample,
• impossibility of fourth vaccination,
• children yet vaccinated or non eligible for vaccination.