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The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-surgical peridontal treatment | Other | Patients with chronic periodontitis received non-surgical periodontal treatment, including scaling and root planing and polishing within 14 days under local anesthesia with manual and ultrasonic devices and standardized oral hygiene instructions including methods of tooth-brushing and interdental cleaning were also given to each one. A professional supragingival plaque control was applied on a regular basis every month. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-surgical periodontal treatment | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Asymmetric dimethylarginine (ADMA) | Serum Concentration (pg/mL) | At the 3rd months after non-surgical periodontal treatment |
| Endothelial nitric oxide synthase (eNOS) | Serum Concentration (pg/mL) | At the 3rd months after non-surgical periodontal treatment |
| Homocysteine (Hcy) | Serum Concentration (nmol/mL) | At the 3rd months after non-surgical periodontal treatment |
| Monocyte chemoattractant protein-1 (MCP-1) | Serum Concentration (ng/mL) | At the 3rd months after non-surgical periodontal treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical periodontal parameter | Clinical attachment level (mm) | At the 3rd months after non-surgical periodontal treatment |
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Inclusion Criteria:
Clinical diagnosis of severe chronic periodontitis
Clinical diagnosis of periodontal health
Exclusion Criteria:
Systemic diseases such as diabetes, cardiovascular disease
Periodontal treatment within the previous year
Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months
Pregnant or lactating
Consumed alcohol
Smoker
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| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |