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A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with periodontitis and without any cardiovascular disease.
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with periodontitis and without any cardiovascular disease.
60 patients with periodontitis treated with non surgical approach through Quadrant subgingival debridement or MINST.
All the patients are assessed for clinical, periodontal, blood and non-invasive ultrasound cardiovascular parameters. Measurements are taken before and after initial periodontal treatment in the periodontal subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Periodontitis - MINST | Experimental | Subjects diagnosed with periodontitis according to the most recent international guidelines and without cardiovascular diseases treated with MINST approach. |
|
| Periodontitis - Q-SI | Placebo Comparator | Subjects with periodontitis and without CVD treated by Q-SI approach |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-surgical periodontal treatment by Q-SI | Procedure | Subgingival biofilm ultrasonic debridement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulse Wave Velocity carotid-femoral (PWV-CF) | The speed of pulse wave propagation between carotid-femoral sites | 8 weeks |
| Pulse Wave Velocity carotid-femoral (PWV-CR) | The speed of pulse wave propagation between carotid-radial sites | 8 weeks |
| Carotid Intima-Media Thickness (CIMT) | The thickness of the carotid intima and media | 8 weeks |
| Distensibility Coefficient (DC) | The relative change in luminal area during systole for a given pressure change (pulsed pressure), will be calculated assuming the lumen to be circular. | 8 weeks |
| Advanced Glycation End products (AGEs) | A group of endogenous heterogeneous compounds that are constantly formed under physiological conditions with prooxidant and cytotoxic properties. Measurements are performed by fluorescence spectroscopy technique. | 8 weeks |
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PERIODONTITIS GROUP
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AOU Policlinico G. Rodolico | Catania | 95124 | Italy |
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| Non surgical periodontal debridement using MINST approach | Procedure | Non surgical periodontal treatment using MINST approach |
|
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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