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The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| coronary heart disease patients with periodontitis | Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) > 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. |
| |
| coronary heart disease patients without periodontitisHD | Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Non-periodontitis classified as having PD ≤ 3 mm. |
| |
| non-coronary heart disease patients with periodontitis | Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) > 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. |
| |
| non-coronary heart disease patients without periodontitis | Non-periodontitis classified as having PD ≤ 3 mm. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-surgical periodontal treatment | Procedure | scaling and root planing, home care instruction |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) | 3 months after non-surgical periodontal treatment |
| change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) | 3 months after non-surgical periodontal treatment |
| change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) | 3 months after non-surgical periodontal treatment |
| change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) | 6 months after non-surgical periodontal treatment |
| change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) | 6 months after non-surgical periodontal treatment |
| change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) | 6 months after non-surgical periodontal treatment |
| Measure | Description | Time Frame |
|---|---|---|
| change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing | 3 months after non-surgical periodontal treatment |
| change of pocket depth between baseline and 3 months after non-surgical periodontal treatment |
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Inclusion Criteria:
Exclusion Criteria:
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Outpatients who came to the Hospital for Tropical Medicine, Faculty of Tropical Medicine, Mahidol University or Rajavithi Hospital, Thailand
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| Name | Affiliation | Role |
|---|---|---|
| Supanee Rassameemasmaung, PhD | Mahidol University Faculty of Dentistry | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University | Ratchathewi | Bangkok | 10400 | Thailand | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36194420 | Derived | Ye Z, Cao Y, Miao C, Liu W, Dong L, Lv Z, Iheozor-Ejiofor Z, Li C. Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis. Cochrane Database Syst Rev. 2022 Oct 4;10(10):CD009197. doi: 10.1002/14651858.CD009197.pub5. |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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Depth of periodontal pocket in millimeters |
| 3 months after non-surgical periodontal treatment |
| change of clinical attachment level between baseline and 3 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters | 3 months after non-surgical periodontal treatment |
| change of bleeding on probing between baseline and 6 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing | 6 months after non-surgical periodontal treatment |
| change of pocket depth between baseline and 6 months after non-surgical periodontal treatment | Depth of periodontal pocket in millimeters | 6 months after non-surgical periodontal treatment |
| change of clinical attachment level between baseline and 6 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters | 6 months after non-surgical periodontal treatment |
| Department of Medicine, Rajavithi Hospital |
| Ratchathewi |
| Bangkok |
| 10400 |
| Thailand |
| Mahidol University Faculty of Dentistry | Ratchathewi | Bangkok | 10400 | Thailand |
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |