The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis

The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:

Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?

Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?

Researchers compared participants with severe periodontitis to healthy participants without periodontitis.

Participants with severe periodontitis:

• Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved
• Had full-mouth gum examinations
• Provided blood samples at the start of the study and again at 2 and 6 months after treatment

Healthy participants:

• Had gum examinations
• Provided blood samples for comparison at the start of the study

Inclusion Criteria:

• Young adults aged 19 to 36 years
• At least 20 teeth present
• Clinical attachment loss of at least 5 mm affecting at least 8 teeth
• Bone loss around at least 3 teeth other than incisors and first molars

Exclusion Criteria:

• Systemic disease
• Pregnancy or lactation
• Current or former smoking
• Systemic conditions that could alter the host response
• Medical conditions requiring antibiotic prophylaxis during routine dental procedures
• Antibiotic therapy within the previous 6 months
• Previous periodontal treatment