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The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:
Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?
Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?
Researchers compared participants with severe periodontitis to healthy participants without periodontitis.
Participants with severe periodontitis:
Healthy participants:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Group | No Intervention | The healthy control arm included systemically and periodontally healthy young adults with no periodontal or systemic disease who met the same exclusion criteria as the periodontitis group. Participants did not receive periodontal treatment. They underwent baseline full-mouth periodontal examination and blood sampling to provide healthy reference values. | |
| Periodontitis Group | Active Comparator | The periodontitis arm included systemically healthy young adults with severe periodontitis. Participants underwent baseline full-mouth periodontal examination and blood sampling, received non-surgical periodontal treatment, and were re-evaluated at 2 and 6 months after treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-surgical periodontal treatment | Procedure | Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment | This change is measured in serum, as mg/dl, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. The study was powered on the change in this parameter from baseline to 6 months after treatment. | 6 months |
| The change in HDL cholesterol concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in LDL cholesterol concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in total cholesterol concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in triglyceride concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| Measure | Description | Time Frame |
|---|---|---|
| The change in sulcus bleeding index (SBI) after periodontal treatment | This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul University, Faculty of Dentistry, Department of Periodontology | Istanbul | Turkey (Türkiye) |
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|
| 6 months |
| The change in albumin concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in von Willebrand factor (vWf) level after periodontal treatment | This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in creatinine concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in fibrinogen concentration after periodontal treatment | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in Factor VII level after periodontal treatment | This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in interleukin-1 receptor (IL-1ra) antagonist concentration after periodontal treatment | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in interleukin-6 (IL-6) level after periodontal treatment | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in soluble tumor necrosis factor receptor I (sTNFRI) concentration after periodontal treatment | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in soluble tumor necrosis factor receptor II concentration (sTNFRII) after periodontal treatment | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in tissue plasminogen activator (tPA) concentration after periodontal treatment | This parameter is measured in blood samples, as ng/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. | 6 months |
| The change in plaque index (PI) after periodontal treatment | This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. | 6 months |
| The change in clinical attachment level (CAL) after periodontal treatment | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. | 6 months |
| The change in probing pocket depth (PPD) after periodontal treatment | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. | 6 months |
| The change in level of gingival margin (LGM) after periodontal treatment | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. | 6 months |
| ID | Term |
|---|---|
| D010520 | Aggressive Periodontitis |
| D007249 | Inflammation |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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