Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

Effect of Non Surgical Periodontal Therapy on Levels of Il-17 and Il-18 in Chronic Periodontitis Patients Versus Periodontally Healthy Individuals

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.

Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

Inclusion Criteria:

• Medically free subjects .
• both genders .
• age range between 30 to 60 years old .

Exclusion Criteria:

• Subjects with periodontal surgeries in the last 6 months.
• Subjects with prior use of antibiotics in the last 6 months.
• Smokers.
• Pregnant and lactating females were excluded.
• Lactating females.