Introduction:Migraine is a prevalent disabling primary headache disorder which is classified in two major types; migraine without aura and migraine with aura. The aim of this study was to compare the efficiency of mesotherapy with systemic therapy in pain controlin patients with headache related tomigraine without aura.

Methods: We conducted this prospective parallel randomized controlled trial with the patients admitted to the emergency department with headache related to migraine without aura. One group was treated with mesotherapy, and the control group with intravenous dexketoprofen. Changes in pain intensity at 30th minute, 60th minute, 120th minute and 24th hours after treatment using Visual Analogue Scale (VAS), need to use analgesic drug within 24 hours,re-admission with same complaint to emergency department (ED) within 72 hours, and adverse effect rate of the methods were compared between groups.

Inclusion Criteria:

• 18 years and older age, and (2)
• Admission to Emergency Department (ED) with headache related to the migraine without aura.

Exclusion Criteria:

• Taking analgesic drugs before admission,
• Having VAS score of lower than 4 on admission,
• Having diabetes mellitus,
• Body mass index>30 kg/m2,
• Pregnancy,
• Lactation,
• Having active bleeding or bleeding disorder,
• Having active or recurrent gastrointestinal hemorrhage or ulcer, or history of these conditions,
• Having a serious or life-threatening condition (stroke, intracranial hemorrhage, heart attack, cardiac tamponade, pneumothorax, hemothorax, flail chest, etc.).