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Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain.
Migraine is one of the types of headaches. For the diagnosis of chronic migraine, the headache must last more than 15 days. Nerve blocks, oral medication and neuromodulation are recommended for migraine treatment.Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain. This study was planned to show the effectiveness of mesotherapy in patients with migraine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mesotherapy | Experimental | All participants who received mesotherapy were monitored regularly for the following three months to assess their prognosis and ensure patient adherence to treatment. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocain | Drug | All participants treated with procaine and lidocaine injection for treatment. |
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| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | Baseline |
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 4th week |
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 8th week |
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 12 th week |
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | Baseline |
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | Baseline |
| Duration of attack per month |
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Inclusion Criteria:
- Clinical diagnosis of chronic migraine disease
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elif Ozyigit, MD | Kanuni Sultan Suleyman Research and Training Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kanni Sultan Suleyman Research and Training Hospital | Istanbul | Kucukcekmece | 34303 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20953425 | Background | Costantino C, Marangio E, Coruzzi G. Mesotherapy versus Systemic Therapy in the Treatment of Acute Low Back Pain: A Randomized Trial. Evid Based Complement Alternat Med. 2011;2011:317183. doi: 10.1155/2011/317183. Epub 2010 Sep 1. | |
| 21887905 | Background | Ravishankar K, Tayade H, Mandlik R. Sublingual piroxicam in migraine without aura. J Assoc Physicians India. 2011 Aug;59:494-7. |
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The investigators were undecided
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| ID | Term |
|---|---|
| D006261 | Headache |
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Retrospective analysis of the group that received treatment
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open label
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| 4th week |
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | 8th week |
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | 12th week |
The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration.
| 4th week |
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | 8th week |
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | 12th week |
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | Baseline |
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 4th week |
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 8th week |
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 12th week |