In this study, the investigators planned to compare the effectiveness of an intravenous ibuprofen against an intravenous dexketoprofen among patients (18-65 years) who were admitted to the emergency department (ED) with acute migraine-related headaches and diagnosed migraine without aura.

In this study, patients who presented with migraine-related headache to emergency departments will be included in this study. Two different therapy option are created; first, 400mg intravenous ibuprofen with 10mg intravenous metoclopramide Hcl , second, 50 mg intravenous dexketoprofen with 10mg intravenous metoclopramide Hcl.

Patients's headache scores will be measured with visual analog score (VAS) at the pretreatment and post-treatment periods (0. minutes, 30. minutes, and 60. minutes.) 60 minutes after treatment, as a rescue therapy, 100mg tramadol will be given to patients whose headache score does not decrease by more than 50% from pretreatment-VAS score.

Inclusion Criteria:

• All the patients aged 18-65 years who had been admitted to the ED for headaches and diagnosed acute migraine-related headache according to the International Classification of Headache Disorders-2018 edition
• Patients whose pre-treatment VAS scores are more than 40 point.
• Patients who give written and verbal consent to include study.

Exclusion Criteria:

• Patients had taken any analgesic drugs or drugs for migraine prophylaxis in the last 6 hours
• Patients had a history of allergy to any of the drugs used in this study
• Patients used any anticoagulant-agents,
• Patients had bleeding diathesis
• patients were pregnant,
• patients were breastfeeding mothers
• Patients who had chronic heart disease, chronic liver disease, and chronic kidney disease
• Patients had peptic ulcer
• Patients had a history of acute akathisia or acute dystonia to metoclopramide hcl