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This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hydrogen-rich water | Experimental | Hydrogen-rich water (Rejuvenation, HRW Natural Health Products Inc.)
|
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| Control water | Placebo Comparator | Tap water
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydrogen-rich water | Dietary Supplement | A tablet that produces hydrogen dissolved in a glass of water |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in TeloTAGGG Telomerase PCR activity in serum | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in DNA methylation | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in blood concentration of advanced glycation end product | Baseline vs. 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| FSPE Applied Bioenergetics Lab | Novi Sad | Vojvodina | 21000 | Serbia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28663789 | Background | Xia X, Chen W, McDermott J, Han JJ. Molecular and phenotypic biomarkers of aging. F1000Res. 2017 Jun 9;6:860. doi: 10.12688/f1000research.10692.1. eCollection 2017. | |
| 34601077 | Derived | Zanini D, Todorovic N, Korovljev D, Stajer V, Ostojic J, Purac J, Kojic D, Vukasinovic E, Djordjievski S, Sopic M, Guzonjic A, Ninic A, Erceg S, Ostojic SM. The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Exp Gerontol. 2021 Nov;155:111574. doi: 10.1016/j.exger.2021.111574. Epub 2021 Oct 1. |
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| Control Water | Other | A glass of tap water |
|
| Baseline vs. 6 months post-intervention |
| Change in lipid peroxidation | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in serum FGF21 | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in serum TET2 | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment) | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in facial wrinkling (0-100 scale; higher scores mean worse outcome) | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
| Change in maximal oxygen uptake estimated by step-in-place test | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |