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Postoperative nausea and vomiting after general anesthesia is one of the common anesthetic complications. If the patient is discharged from the hospital after surgery, proper treatment may be delayed or impossible if nausea and vomiting occurred. Thus, it is necessary to prevent these symptoms beforehand. Patients who underwent day-surgery will be treated with prophylactic ramosetron orally disintegrating tablets to determine whether the frequency of nausea and vomiting is decreased when the patient returned home after discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ramosetron-ODT | Experimental |
| |
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ramosetron | Drug | Ramosetron orally disintegrating tablet 0.1 mg is administered after discharge (postoperative day 1 and day 2) |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change in the occurrence of postoperative nausea | Postoperative 30 minute, 3 hour, 24 hour, and 48 hour | |
| The change in the occurrence of postoperative vomiting | Postoperative 30 minute, 3 hour, 24 hour, and 48 hour |
| Measure | Description | Time Frame |
|---|---|---|
| The change in the severity of postoperative nausea | Numerical rating scale range from 0 to 100 (0 = no pain, 100 = the most severe pain imaginable) | Postoperative 30 minute, 3 hour, 24 hour, and 48 hour |
| The change of patient's satisfaction score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyun-Jung Shin, MD., PhD. | Contact | 82317877499 | hjshin.anesth@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hyun-Jung Shin, MD., PhD. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Recruiting | Seongnam-si | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35546414 | Derived | Shin HJ, Park YH, Chang M, Chae YJ, Lee HT, Lee OH, Min SK, Do SH. Effects of ramosetron orally disintegrating tablets on the prophylaxis of post-discharge nausea and/or vomiting in female patients undergoing day surgery under general anesthesia: a randomized controlled trial. Perioper Med (Lond). 2022 May 12;11(1):17. doi: 10.1186/s13741-022-00251-6. |
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| ID | Term |
|---|---|
| C071315 | ramosetron |
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Numerical rating scale range from 0 to 100 (0 = no pain, 100 = the most severe pain imaginable)
| Postoperative 30 minute, 3 hour, 24 hour, and 48 hour |
| The change in the number of postoperative administration of rescue antiemetic drug | Postoperative 30 minute, 3 hour, 24 hour, and 48 hour |