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Patients undergoing general anesthesia for laparoscopic cholecystectomy have a high risk of postoperative nausea and vomiting (PONV). The investigators investigated the effect of oral and IV ramosetron on PONV prophylaxis after laparoscopic cholecystectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group I | Active Comparator | 0.3 mg IV ramosetron |
|
| group II | Active Comparator | 0.1 mg oral ramosetron |
|
| group III | Active Comparator | 0.1 mg oral ramosetron plus 0.3 mg IV ramosetron |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intravenous ramosetron | Drug | 0.3 mg IV ramosetron (group I) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of PONV | postoperative 0-48 h |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jung-Hee Ryu, Ph.D | Contact | 82-31-787-7497 | jinaryu@lycos.co.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jung-Hee Ryu | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21856001 | Derived | Ryu JH, Jeon YT, Hwang JW, Oh AY, Moon JY, Ro YJ, Kim CS, Chen C, Apfel CC, Do SH. Intravenous, oral, and the combination of intravenous and oral ramosetron for the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, controlled trial. Clin Ther. 2011 Sep;33(9):1162-72. doi: 10.1016/j.clinthera.2011.07.018. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 23, 2010 | |
| Reset | Aug 18, 2010 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 23, 2010 | Aug 18, 2010 |
| ID | Term |
|---|---|
| D009325 | Nausea |
| D014839 | Vomiting |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C071315 | ramosetron |
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| oral ramosetron |
| Drug |
0.1 mg oral ramosetron (group II) |
|
| oral and IV ramosetron | Drug | 0.1 mg oral ramosetron plus 0.3 mg IV ramosetron (group III). |
|