Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy

A Randomized Prospective Study of Scheduled Intravenous Ramosetron for the Prevention of Nausea and Vomiting in Hospitalized Patients After Gynecologic Laparoscopy

To compare postoperative nausea and vomiting (PONV) and perioperative outcomes of gynecologic patients undergoing laparoscopic surgery after scheduled administration of intravenous Ramosetron during hospital stays.

• Randomized controlled arm : Placebo versus Ramosetron injection
• Administration schedule : immediate postoperative status, 12 hrs after surgery, 36hrs after surgery

Surgical outcomes including operative time, blood loss, Hb change, postoperative pain, nausea/vomiting scale, times of rescue therapy, and complications

Inclusion Criteria:

• Age: 18< or =, = or <70 with benign gynecologic disease
• ASA-Class I-II
• No-definite malignancy by US, CT/MRI, CA 125 < 500IU/ml
• Non-smoker

Exclusion Criteria:

• Conversion to laparotomy
• Hx of malignancy
• Smoker
• Suspicious malignancy