Kisspeptin/GPR54 Pathway and Early Puberty

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Inclusion Criteria:

- Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria:

• The participants who were not the first visit to the hospital and had been treated before.
• The participants who were with endocrine disorders.