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There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cases | Early puberty cases of Han Chinese | ||
| controls | Controls were matched to cases at 1:1 by age (± 3 months) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| this study was an observational study and no interventions were given to the participants | Other | the participants were recruited and the data as well as blood sample were collected. |
| Measure | Description | Time Frame |
|---|---|---|
| the polymorphism in the KISS1/GPR54 pathway genes | functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected. | 3 months |
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Inclusion Criteria:
- Clinical diagnosis of central precocious puberty or early and fast puberty.
Exclusion Criteria:
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Chinese Han girls from Shenzhen Children's Hospital or monitoring schools in Shenzhen
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32160304 | Derived | Li D, Wu Y, Cheng J, Liu L, Li X, Chen D, Huang S, Wen Y, Ke Y, Yao Y, Su Z, Zhou L. Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz229. doi: 10.1210/clinem/dgz229. |
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| ID | Term |
|---|---|
| D011629 | Puberty, Precocious |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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