The Molecular Basis of Inherited Reproductive Disorders

The Molecular Basis of Inherited Reproductive Disorders

The goal of this study is to learn more about the genes that control puberty and reproduction in humans.

All study subjects will undergo the same activities. Subjects will provide up to five tubes of blood for genetic analysis, complete a smell test, and answer questions about their health and family history.

Participants must be healthy controls or belong to one of the following categories:

• Failure to go through a normal, age-appropriate, spontaneous puberty and low sex steroid levels in the setting of low/normal gonadotropins or,
• Abnormally early development of puberty or,
• Normal puberty with subsequent development of low gonadotropin levels or,
• Evidence of a reproductive disorder with high gonadotropin levels or,
• Pre-pubertal individuals with features suggestive of hypogonadotropic hypogonadism or,
• Affected and unaffected family members of individuals that fit criteria above