the Association Between Obesity and Early Puberty

Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Inclusion Criteria:

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria:

• The participants who were not the first visit to the hospital and had been treated before.
• The participants who were with endocrine disorders.