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This study aims to compare the retinal perfusion between diabetic and non-diabetic patients with Optical Coherence Tomography(OCT) Angiography after cataract surgery, to thoroughly evaluate the retinal state of diabetics after surgery, and to find out the relationship between postoperative complications occurred in retina and diabetes.
In this study, we perform a completely comparison of retina state characteristic including the foveal avascular zone(FAZ),perifovea vessel density,parafovea vessel density,macular thickness,perifovea thickness,parafovea thickness in superficial and deep layers of retina with OCT Angiography after cataract surgery,and analysis on the differences of EGF,IFN-γ,IL-10,IL-12,IL-1β,IL-6,IL-8,IP-10,MCP-1,VEGF in aqueous humor before surgery between diabetic and non-diabetic patients and to explore the potential correlations between postoperative complications occurred in retina and diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| diabetic patients after cataract surgery | diabetic patients after cataract surgery | ||
| non-diabetic patients after cataract surgery | non-diabetic patients after cataract surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| OCT Angiography parameters | comparison of vessel density in superficial and deep layers of retina between diabetic and non-diabetic patients with OCT Angiography. | 3 months postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| aqueous humor cytokines levels | comparison the levels of cytokines from aqueous humor including EGF,IFN-γ,IL-10,IL-12,IL-1β,IL-6,IL-8,IP-10,MCP-1,VEGF between diabetic and non-diabetic patients. | intraoperatively. |
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Inclusion Criteria:
Exclusion Criteria:
Elimination Criteria:
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Study Population: Asian
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| Name | Affiliation | Role |
|---|---|---|
| Hong Qi, MD | Peking University Third Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Beijing | Beijing Municipality | 100191 | China |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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aqueous humor from the subjects