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Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with diabetes and retinopathy.
Relieving the burden of diabetic retinopathy treatment require a prompt and non-invasive assessment of diabetic patients before the occurence of diabetic retinopathy. Since OCT is capable of imaging retina with such a high precision, retinal changes occuring before any clinical signs of retinopathy, such as microaneurysm or haemorrhages, can now be assessed. In the present study the investigators are analyzing the connection between retinal arteries and veins regarding lumen diameter, vessel wall thickness and their correlation with retinal nerve fiber layer and ganglion cell layer thickness. Moreover, using binarization of the choroid the investigators will assess its relationship with outer retina layers, such as retinal pigment epithelium and photoreceptors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control |
| ||
| Diabetes mellitus without Diabetic Retinopathy |
| ||
| Diabetes mellitus with Diabetic Retinopathy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical Coherence Tomography | Diagnostic Test | Spectral Domain Optical Coherence Tomography(SD-OCT) examination will be performed for every patient: posterior pole scan, EDI-OCT(enhanced depth imaging-OCT) and peripapillary RNFL(retinal nerve fiber layer) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between choroid and outer retina using SD-OCT- based binarization technique | starting from EDI-OCT scans the investigators will analyze choroidal parameters such as Luminal area, Stromal area, Total choroidal area, Chorodial vascularity index and correlate them with retinal pigment epithelium (RPE),outer nuclear layer(ONL) and photoreceptors' thickness (PR) | 2018-2019 |
| Correlation between neurodegeneration and retinal vessels characteristics | using full width at half maximum method, the investigators will measure peripapillary arteries and veins' diameters, their wall thickness and correlate them with RNFL and ganglion cell layer(GCL) thickness | 2018-2019 |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between choroidal parameters and their influence on Best corrected visual acuity(BCVA) | The investigators will analyze if changes in the choroid will influence patients' visual acuity. For statistical reasons, visual acuity will be converted to logMAR(logarithm of the minimum angle of resolution) | 2018-2019 |
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Inclusion Criteria:
Exclusion Criteria:
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All participants were recruited between July 2018 and July 2019 at Department of Ophthalmology, Emergency County Hospital Cluj, Romania. Healthy subjects were recruited from patients scheduled for routine ocular examination at Department of Ophthalmology, Emergency County Hospital Cluj, Romania
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| Name | Affiliation | Role |
|---|---|---|
| Ioana Damian, MD | Iuliu Hatieganu University of Medicine and Pharmacy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Medicine and Pharmacy " Iuliu Hatieganu" | Cluj-Napoca | Romania |
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After the papers will be published.
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| ID | Term |
|---|---|
| D003930 | Diabetic Retinopathy |
| D009410 | Nerve Degeneration |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D003925 | Diabetic Angiopathies |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| Correlation between renal function and choroidal parameters |
Using estimated glomerular filtration rate(eGFR-mL/min/1.73 m2) the investigators will analyze if a decreased eGFR will produce changes in choroidal architecture |
| 2018-2019 |
| Correlation between sistemic factors and choroidal parameters | The investigators will document if the presence of High Blood pressure(yes/no) and current smoking(yes/no) influences choroidal thickness or CVI. | 2018-2019 |
| Correlation between choroidal parameters and diabetes control | Using HbA1c(Glycated haemoglobin) the investigators will analyze the choroidal's behaviour under different HbA1c levels. | 2018-2019 |
| D002318 |
| Cardiovascular Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |