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Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MCT intake in young participants | Experimental | Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions:
|
|
| MCT intake in older participants | Experimental | Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in older participants. Interventions:
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No MCT intake with breakfast, no lunch | Dietary Supplement | Water given with a regular standardize breakfast and water given at noon without lunch. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate) | To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of plasma glucose | To compare acute glucose following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours |
| Concentration of plasma insulin |
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Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rearsh Centre on Aging | Sherbrooke | Quebec | J1H4C4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26766547 | Background | Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20. doi: 10.1111/nyas.12999. Epub 2016 Jan 14. | |
| 28709938 |
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10 young and 10 older participants undergoing six separate but identical metabolic visits (interventions)
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|
| No MCT intake with lunch, no breakfast | Dietary Supplement | Water given in the beginning of the metabolic study day without breakfast and water given at noon with a regular standardize lunch. |
|
|
| 10g of Betaquik | Dietary Supplement | BQ10 given with a regular standardize breakfast and BQ10 given at noon without lunch. |
|
|
| 10g of Betaquik with low-carbs breakfast | Dietary Supplement | BQ10 given with a low-carbs standardize breakfast and BQ10 given at noon without lunch. |
|
|
| 20g of Betaquik | Dietary Supplement | BQ20 given with a regular standardize breakfast and BQ20 given at noon without lunch. |
|
|
| 10g of Betaquik with lunch, no breakfast | Dietary Supplement | BQ10 given in the beginning of the metabolic study day without breakfast and BQ10 given at noon with a regular standardize lunch. |
|
|
To compare acute insulin following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.
| 8 hours |
| Concentration of plasma free fatty acids | To compare acute free fatty acids following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours |
| Croteau E, Castellano CA, Fortier M, Bocti C, Fulop T, Paquet N, Cunnane SC. A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease. Exp Gerontol. 2018 Jul 1;107:18-26. doi: 10.1016/j.exger.2017.07.004. Epub 2017 Jul 12. |
| 27629100 | Background | Courchesne-Loyer A, Croteau E, Castellano CA, St-Pierre V, Hennebelle M, Cunnane SC. Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493. doi: 10.1177/0271678X16669366. Epub 2016 Jan 1. |
| 23274095 | Background | Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, Chouinard-Watkins R, Roy M, Nugent S, Castellano CA, Cunnane SC. Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. Nutrition. 2013 Apr;29(4):635-40. doi: 10.1016/j.nut.2012.09.009. Epub 2012 Dec 28. |
| 25147107 | Background | Castellano CA, Nugent S, Paquet N, Tremblay S, Bocti C, Lacombe G, Imbeault H, Turcotte E, Fulop T, Cunnane SC. Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer's disease dementia. J Alzheimers Dis. 2015;43(4):1343-53. doi: 10.3233/JAD-141074. |
| ID | Term |
|---|---|
| D007662 | Ketosis |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
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| ID | Term |
|---|---|
| D062408 | Breakfast |
| D062409 | Lunch |
| ID | Term |
|---|---|
| D062407 | Meals |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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