Ketone Production With Acute Caffeine Intake

Stimulate the Ketogenesis by Using a Caffeine Supplement

Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Inclusion Criteria:

• Healthy adults
• 18 years old and over

Exclusion Criteria:

• Drinking more than 300 mg of caffeine per day
• Diabetes or prediabetes
• Abnormal liver and kidney function
• Uncontrolled dyslipidemia, blood pressure
• Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.)
• Severe inflammation or infection
• Pregnancy
• Smoking