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The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ketone monoester | Experimental | Acute morning dose of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (0.45 ml/kg body weight) |
|
| Placebo | Placebo Comparator | Acute morning dose of flavour-matched placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketone monoester | Dietary Supplement | Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour high carbohydrate mixed meal tolerance test. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose area under the curve | Area under the curve for glucose during high carbohydrate mixed meal tolerance test | 2-hour |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin area under the curve | Insulin area under the curve during high carbohydrate mixed meal tolerance test | 2-hour |
| Free fatty acids area under the curve | Non-esterified fatty acids area under the curve during high carbohydrate mixed meal tolerance test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia, Okanagan | Kelowna | British Columbia | V1V 1V7 | Canada |
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Crossover assignment
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Placebo masked with flavouring and participants consume in opaque containers
| Placebo | Dietary Supplement | Acute ingestion of a taste-matched placebo prior a 2-hour high carbohydrate mixed meal tolerance test. |
|
| 2-hour |
| Glucose incremental area under the curve | Incremental area under the curve (above baseline) for glucose during high carbohydrate mixed meal tolerance test | 2-hour |
| Insulin incremental area under the curve | Incremental area under the curve (above baseline) for insulin during high carbohydrate mixed meal tolerance test | 2-hour |
| 2-hr glucose level | Plasma glucose assessed 2-hr after high carbohydrate mixed meal tolerance test | 2-hour |
| Beta-hydroxybutyrate level | Blood beta-hydroxybutyrate concentration assessed by handheld monitor | 2-hour |