Comparing the Ketogenic Effect of Coconut Oil and Different MCTs

Comparing the Ketogenic Effect of Coconut Oil and Different Medium-chain Triglycerides

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Inclusion Criteria:

• Healthy adult over 18 y old.

Exclusion Criteria:

• Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
• Smoking
• Clinically-significant gastro-intestinal disease/conditions.
• Clinically-significant liver disease/dysfunction.
• Clinically-significant cardiac disease/conditions.
• Clinically-significant abnormal coagulation.
• Taking a medication that could affect lipid and glucose metabolism
• Hypertension
• Pregnancy or breastfeeding
• Exercising more than 3 times a week