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The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.
The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplementation | Experimental | Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coconut oil | Dietary Supplement | 20 g of coconut oil |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Ketone Concentrations | Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here. | 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Acetoacetate/Beta-hydroxybutyrate Ratio | Plasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours). | 8 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephen Cunnane, PhD | CSSS-IUGS - CIUSSS de L'Estrie - CHUS - Université de Sherbrooke | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS) | Sherbrooke | Quebec | J1H4C4 | Canada |
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| ID | Title | Description |
|---|---|---|
| FG000 | Supplementation | Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. Coconut oil: 20 g of coconut oil Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10) MCT: 20 g of MCT (60 of C8+40 of C10) Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin Tricaprylin: 20 g tricaprylin Tricaprin: 20 g tricaprin Control: No supplement taken on this visit |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Supplementation | Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. Coconut oil: 20 g of coconut oil Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10) MCT: 20 g of MCT (60 of C8+40 of C10) Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin Tricaprylin: 20 g tricaprylin Tricaprin: 20 g tricaprin Control: No supplement taken on this visit |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Plasma Ketone Concentrations | Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here. | Posted | Mean | Standard Deviation | µmol/L | 8 hours |
|
7 visits of 8 hours
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Supplementation | Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. Coconut oil: 20 g of coconut oil Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10) MCT: 20 g of MCT (60 of C8+40 of C10) Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin Tricaprylin: 20 g tricaprylin Tricaprin: 20 g tricaprin Control: No supplement taken on this visit |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Pr. Stephen Cunnane | Université de Sherbrooke | 819-780-2220 | 45670 | stephen.cunnane@usherbrooke.ca |
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| ID | Term |
|---|---|
| D007662 | Ketosis |
| ID | Term |
|---|---|
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000074263 | Coconut Oil |
| C003637 | tricaprylin |
| C010800 | tricaprin |
| D015260 | Neprilysin |
| ID | Term |
|---|---|
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 |
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| Coconut oil + MCT | Dietary Supplement | 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10) |
|
|
| MCT | Dietary Supplement | 20 g of MCT (60 of C8+40 of C10) |
|
| Coconut oil + tricaprylin | Dietary Supplement | 10 g coconut oil + 10 g tricaprylin |
|
|
| Tricaprylin | Dietary Supplement | 20 g tricaprylin |
|
|
| Tricaprin | Dietary Supplement | 20 g tricaprin |
|
|
| Control | Dietary Supplement | No supplement taken on this visit |
|
|
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| Body mass index | Mean | Standard Deviation | kg/m^2 |
|
| Glucose | Mean | Standard Deviation | mmol/L |
|
| Ketones | Mean | Standard Deviation | µmol/L |
|
| Tricaprin |
20 mL of MCT tricaprin taken twice, once at breakfast and once at mid-day. Tricaprin: 20 g tricaprin |
| OG003 | Tricaprylin | 20 mL of tricaprylin taken twice, once at breakfast and once at mid-day. Tricaprylin: 20 g tricaprylin |
| OG004 | Coconut Oil | 20 mL of Coconut oil taken twice, once at breakfast and once at mid-day. Coconut oil: 20 g of coconut oil |
| OG005 | Coconut Oil + MCT | 20 mL of coconut oil + MCT taken twice, once at breakfast and once at mid-day. Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10) |
| OG006 | Coconut Oil + Tricaprylin | 20 mL of Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day. Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin |
|
|
| Secondary | Plasma Acetoacetate/Beta-hydroxybutyrate Ratio | Plasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours). | Posted | Mean | Standard Deviation | Ratio | 8 hours |
|
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| 9 |
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| 9 |
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| Oils |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D000951 | Antigens, Neoplasm |
| D000941 | Antigens |
| D001685 | Biological Factors |
| D014408 | Biomarkers, Tumor |
| D015415 | Biomarkers |