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| Name | Class |
|---|---|
| Fondation Vitae | OTHER |
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Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alzheimer's disease | Experimental | Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized) |
|
| Controls | Experimental | Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1-month of 60-40 MCT oil | Dietary Supplement | 1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of brain glucose uptake | Brain glucose uptake (umol/100g/min) using 18-FDG PET scan | 1-month |
| Quantification of brain acetoacetate uptake | Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET scan | 1-month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephen Cunnane, PhD | Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS) - Université de Sherbrooke | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS) | Sherbrooke | Quebec | J1H4C4 | Canada |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 1-month of C8 MCT oil | Dietary Supplement | 1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl) |
|
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |