Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease

Proof of Concepts: Can a Supplement Ketogenic Based MCT Oil Increases Cerebral Capture Ketones in People With Alzheimer's Disease?

Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.

Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.

Inclusion Criteria:

• Good general health for Control group
• Diagnosis of Alzheimer's disease (NINCDS-ADRDA criteria) for AD group

Exclusion Criteria:

• Depression
• Medical or psychiatric conditions that could interfere with study participation
• Fasting plasma glucose ≥7.0 mM (diabetes or prediabetes)
• Already on MCT supplementation
• Clinically-significant gastrointestinal disease/conditions
• Clinically-significant liver disease/dysfunction
• Clinically-significant renal disease/dysfunction
• Clinically-significant cardiac disease/conditions
• Hypertension
• Uncontrolled dyslipidaemia
• Vitamin B12 deficiency
• Structured physical activity (more than 3 times/week)