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High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.
Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water + Meal | Active Comparator | 250 ml Water and a high calorie, high fat meal (>900 kcal, 50g fat) |
|
| Red Wine + Meal | Experimental | 250 ml Red Wine and a high calorie, high fat meal (>900 kcal, 50g fat) |
|
| Green Tea + Meal | Experimental | 250 ml Green Tea and a high calorie, high fat meal (>900 kcal, 50g fat) |
|
| Orange Juice + Meal | Experimental | 250 ml Orange Juice and a high calorie, high fat meal (>900 kcal, 50g fat) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water | Other | 250 ml |
| |
| Red Wine |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial (dys)function | Assessed via flow mediated dilatation | 2 hours post-prandial |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Nitrite | 2 hours post-prandial | |
| Plasma antioxidant capacity | Plasma oxygen radical absorbance capacity | 2 hours post-prandial |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ian Megson, Megson | University of the Highlands and Islands | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of the Highlands and Islands | Inverness | IV2 3JH | United Kingdom |
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| ID | Term |
|---|---|
| D014867 | Water |
| D013662 | Tea |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Other |
250 ml |
|
| Green Tea | Other | 250 ml |
|
| Orange Juice | Other | 250 ml |
|
| Plasma ox-LDL |
| 2 hours post-prandial |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |