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| ID | Type | Description | Link |
|---|---|---|---|
| RN08BI013 |
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The purpose of this study is to assess the effects of a novel beverage rich in polyphenols (compounds present in fruit extracts) on risk factors associated with cardiovascular disease.
This study will assess the potential of a beverage containing plant and fruit extracts rich in polyphenolics to modulate vascular risk.
Novel risk factors for vascular disease will be assessed including non-invasive assessment of vascular function by pulse wave analysis / pulse wave velocity and laser doppler iontophoresis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beverage | Placebo Comparator |
| |
| High Polyphenol Beverage | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High polyphenol beverage | Dietary Supplement | Antioxidant capacity umol TE/L(ORAC): 19987 Polyphenolic Content(mcg/ml): 1445 Vitamin C (mg/100ml): 35.35 Calorie Content (Kcal/250ml):40.0 250ml twice daily for 1 month (56 doses) |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular Function (measured by Laser Doppler Iontophoresis and Pulse Wave Analysis / Pulse Wave Velocity) | Baseline and post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Established and novel blood markers for vascular disease | baseline and post intervention |
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Inclusion Criteria:
Exclusion Criteria:
cardiorespiratory, rheumatological, cerebrovascular or neoplastic disease)
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adam WF Mullan, MBChB MRCP | Contact | +44-141-330-2569 | a.mullan@clinmed.gla.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Naveed Sattar, MBChB PhD FRCPath FRCP | University of Glasgow | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| British Heart Foundation Glasgow Cardiovascular Research Centre | Recruiting | Glasgow | G12 8TA | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26797134 | Derived | Mullan A, Delles C, Ferrell W, Mullen W, Edwards CA, McColl JH, Roberts SA, Lean ME, Sattar N. Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial. Atherosclerosis. 2016 Mar;246:169-76. doi: 10.1016/j.atherosclerosis.2016.01.004. Epub 2016 Jan 6. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Placebo Beverage | Dietary Supplement | Antioxidant capacity umol TE/L(ORAC): negligible Polyphenolic Content(mcg/ml): negligible Vitamin C (mg/100ml): 0.00 Calorie Content (Kcal/250ml):40.0 250ml twice daily for 1 month (56 doses) |
|