The objective is to conduct an RCT to evaluate the effectiveness of Licorice in comparison to standard caries preventive measures for the prevention of new carious lesions in high caries risk patients.

Research hypothesis (Null hypothesis):

The present clinical trial will be conducted to reject or accept the null hypothesis that using Licorice extract mouth wash in addition to standard preventive measures will not differ from using standard preventive measures alone in preventing incidence of new carious lesions.

PICOTS:

P: Population with high caries risk patients

I: Use of licorice.

I2: Use of chlorhexidine

C: Use of standard preventive measures (tooth brushing, tooth paste, interdental cleaning).

O.1: Primary outcome is incidence of new carious lesions

T: Time for measurement is 12 months

S: A Randomized controlled clinical trial (Parallel study)

Inclusion Criteria:

• Patients with high caries risk,
• 18-25 years,
• Males or females,
• Medically free patients,
• Patients approving to participate in the study.

Exclusion Criteria:

• Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination,
• Patients had history of professional cleaning in the last 15 days,
• Patients with exposed pulp,
• Evidence of parafunctional habits,
• Patients with developmental dental anomalies,
• Patients undergoing or will start orthodontic treatment,
• Patients with removable prosthesis,
• Periapical Abscess or Fistula.