66 Participants will be divided into three groups according to the tested regimen (A), where (A1) represents participants exposed to fluoride toothpaste, (A2) represents participants exposed to regimen including fluoride toothpaste and chlorhexidine mouthwash and (A3) represents participants exposed to regimen including fluoride toothpaste, chlorhexidine mouthwash and MI fluoride varnish. The study will be carried over a period of one year, assessment of cariogram will be done in two visits: first visit (baseline: T0) and second visit (after 3 months: T2). In addition assessment of DMF scores will be done in four visits: first visit (baseline: T0), second visit (after 3 months: T1), third visit (after 6 months: T2) and final visit (after 12 months: T3) to obtain the required data

Inclusion Criteria:

• Age range 20-50 years
• High caries risk patients defined according to cariogram caries risk assessment model
• On non-cariogenic diet
• High plaque index
• Systematically healthy
• No orthodontic or prosthodontic appliance

Exclusion Criteria:

• Age range less than 20 or more than 50 years
• Low or moderate caries risk patients according to cariogram
• Patients with a compromised medical history
• Cariogenic diet patient
• Participants with a history of allergy to any of the drugs or chemicals used in the study
• Patients on any antibiotics during the past month