Basic standard of care emphasis only tooth brushing and flossing without addressing individual pathological factors. For this reason, randomized controlled clinical trials on personalized caries management are needed to be able to compare the effectiveness of personalized caries management to basic standard of care. This is especially true in high caries risk populations and more so for young adults who stand to benefit the most from working towards a caries free adulthood.

Aim of the study: is to conduct an RCT to compare the effectiveness of a new personalized caries-control treatment protocol with standard caries treatment protocol for reducing caries incidence in high caries risk patients

Hypothesis: This project will be designed to test the null hypothesis that there is no significant difference between the new personalized caries-control treatment protocol and existing standard caries treatment protocol, and to test the alternative hypothesis that the new personalized treatment protocol will be superior to the standard preventive measures

Primary objective: is to measure the incidence of new caries lesions

Inclusion Criteria:

1. High caries risk patients
2. 18-25 years
3. Males or Females
4. Patients approving to participate in the study -

Exclusion Criteria:

• Patients with systemic conditions
• Current periodontitis (sites of probing pocket depth ≥ 5 mm)
• Allergy to any of the ingredients of the study products
• Evidence of parafunctional habits
• Dysfunction of temporomandibular joint
• Use of antibiotics in the previous 30 days
• Patients with developmental dental anomalies
• Patients with removable prosthesis
• Patients with Orthodontic appliance
• Periapical Abscess or Fistula and exposed pulps.

Data will be made available after publication upon request

12 month after publication , data will be available upon request

principal investigator to be contacted by email for data access

The recruiter will be blinded. The operator cannot be blinded because of the different in the procedures of caries prevention applied in each group. However, the assessors will be kept unaware of the treatment assigned to the patient.