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The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.
Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GLU+EX | Experimental | Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol. |
|
| GLU | Active Comparator | Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GLU+EX | Behavioral | Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Vascular Endothelial Function | Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention. | Before and after the seven-day intervention in both groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Central Blood Pressure | Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions. | Before and after the seven-day intervention in both groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Activity | Steps per day will be recorded via accelerometry throughout the intervention in both groups. | Continuously throughout the seven-day intervention. |
| Caloric Consumption | Subjects will record their dietary intake throughout the intervention. |
Inclusion Criteria:
- Healthy young men 18-35 years of age.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Education Building | Iowa City | Iowa | 52242 | United States |
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| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001519 | Behavior |
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Randomized
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| GLU | Dietary Supplement | Subjects will consume a 75g glucose beverage three times daily over a seven-day period. |
|
| Continuously throughout the seven-day intervention. |