Hyperglycemia, Exercise, and Endothelial Function

Effect of Short-Term Glucose Loading on Vascular Function

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Inclusion Criteria:

- Healthy young men 18-35 years of age.

Exclusion Criteria:

• Hypertension,
• Hyperlipidemia,
• Smoking,
• Heart disease,
• Chest pain upon exertion,
• Previous heart surgeries or history of arrhythmias,
• Diabetes,
• Obesity (body mass index ≥30kg/m2),
• Kidney disease,
• Pulmonary disease,
• Autonomic disorders,
• Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
• Current use of medications which influence outcome measures