Glucotoxicity and Acute Exercise

The Effects of Hyperglycaemia on the Response to Acute Exercise

Experimental hyperglycemia (5 hours) will be induced via a constant- or fluctuating-rate glucose infusion to establish different patterns of glycemia in healthy individuals. The effects of these acute models of hyperglycemia on the adaptations to a single aerobic exercise bout will be tested. Changes in pancreatic endocrine function, insulin sensitivity, endothelial function, and oxidative stress will be measured.

Inclusion criteria for participation:

• Male
• Age 18-50 years
• Body Mass Index 19-30 kg/m2
• Generally healthy

Exclusion criteria for participation:

• Regular use of anti-inflammatory medication
• Smokers
• More than 2 kg weight change in prior 6 months
• Previous weight loss surgery
• Cancer, or evidence of chronic haematological, pulmonary, cardiac, hepatic, renal, or gastrointestinal disease
• Evidence of diabetes
• Engaged in moderate or vigorous activity on more than 5 days per week