Acute Exercise and Pancreatic Endocrine Function

Subjects with type 2 diabetes will be stratified into two-quantiles based on ambient hyperglycemia (fasting glucose and HbA1c) and then the effects of a single aerobic exercise bout (1-hour at 50%VO2max) on pancreatic endocrine function will be determined.

Inclusion Criteria:

• Previous diagnosis with type 2 diabetes, or newly detected in our screening procedures
• Age 30-70 years
• BMI 20-40 kg/m2

Exclusion Criteria:

• Treatment with insulin
• Contraindication to exercise as determined by ECG
• Pregnancy
• Active weight loss in the previous 6 months
• Actively engaged in exercise training programs
• Evidence of chronic pulmonary, cardiovascular, hepatic, renal, or hematological disease