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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
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Effects of GLP-2 and GIP on bone remodeling in healthy young men.
We will investigate acute effects of GLP-2 and GIP on bone remodeling in healthy young men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GLP-2 | Experimental | Glucagon-Like Peptide-2 (GLP-2) injection |
|
| GIP | Experimental | Glucose-dependent Insulinotropic polypeptide (GIP) injection |
|
| GLP-2+GIP | Experimental | GLP-2+GIP injection |
|
| Placebo | Placebo Comparator | Placebo injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GLP-2 | Other | GLP-2 |
| |
| GIP |
| Measure | Description | Time Frame |
|---|---|---|
| Bone resorption | C-terminal telopeptide (CTX) is a marker of bone resorption. Measured in serum. | From -10 minutes to 240 minutes. |
| Bone formation | P1NP is a marker of bone formation. Measured in serum. | From -10 minutes to 240 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Parathyroid hormone | PTH is a bone marker | From -10 minutes to 240 minutes. |
| Calcium | Measured in serum. | From -10 minutes to 240 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Before blood sampling | From -10 minutes to 240 minutes. |
| Blood pressure | Before blood sampling | From -10 minutes to 240 minutes. |
Inclusion Criteria:
Age between 20 and 40 years old Caucasian Healthy BMI between 18.5 and 24.9 kg/m2.
Exclusion Criteria:
Chronic disease Smoking Medication Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<8,0 mmol/L Decreased renal function.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | 2650 | Denmark |
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| Other |
GIP |
|
| GLP-2+GIP | Other | GLP-2+GIP |
|
| Placebo | Other | Placebo |
|
| GIP | Intact and total GIP. | From -10 minutes to 240 minutes. |
| GLP-2 | Intact GLP-2 | From -10 minutes to 240 minutes. |
| Glucose | Measured in serum. | From -10 minutes to 240 minutes. |
| Insulin | Measured in serum. | From -10 minutes to 240 minutes. |
| C-peptide | Measured in serum. | From -10 minutes to 240 minutes. |
| Sclerostin | Bone marker. | From -10 minutes to 240 minutes. |