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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
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Glucagon-like peptide-2 (GLP-2) is a naturally occuring hormone secreted to the circulation in response to food ingestion. Previous studies have shown that GLP-2 and incretins inhibit the bone resorption. However, the mechanism is unknown. In the present study we will investigate the mechanism of action using a receptor specific inhibitor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inhibitor + GLP-2 | Experimental |
| |
| Placebo + GLP-2 | Experimental |
| |
| Placebo + GIP | Active Comparator |
| |
| Placebo + Saline | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inhibitor + GLP-2 | Other | Inhibitor and GLP-2 are used as study tools. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| C-terminal telopeptide (CTX) | Marker of bone resorption | -30 to 240 min. |
| Measure | Description | Time Frame |
|---|---|---|
| N-terminal propeptide of type 1 procollagen (P1NP) | Marker of bone formation | -30 to 240 min. |
| Osteocalcin (OC) | Bone marker | -30 to 240 min. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mette Rosenkilde, MD | University of Copenhagen | Study Director |
| Sten Madsbad, MD | Hvidovre University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31100534 | Derived | Skov-Jeppesen K, Svane MS, Martinussen C, Gabe MBN, Gasbjerg LS, Veedfald S, Bojsen-Moller KN, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B. GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men. Bone. 2019 Aug;125:178-185. doi: 10.1016/j.bone.2019.05.014. Epub 2019 May 15. |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| Placebo + GLP-2 |
| Other |
Placebo and GLP-2 are used as study tools. |
|
| Placebo + GIP | Other | Placebo and GIP are used as study tools. |
|
| Placebo + Saline | Other | Placebo |
|
| Parathyroid hormone (PTH) | Bone marker | -30 to 240 min. |
| Osteoprotegerin (OPG) | Bone marker | -30 to 240 min. |
| Glucose-dependent insulinotropic polypeptide (GIP) | GIP total and intact | -30 to 240 min. |
| Glukagon-like peptide-1 (GLP-1) and glukagon-like peptide-2 (GLP-2) | -30 to 240 min. |
| Glukagon and pancreatic polypeptide (PP) | -30 to 240 min. |
| Glucose | -30 to 240 min. |
| Insulin/c-pep. | -30 to 240 min. |
| D017670 |
| Sodium Compounds |