Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury

Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury

Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.

Inclusion Criteria (Individuals with spinal cord injury):

• Spinal cord injury resulting in the need of a wheelchair
• BMI: 16-32 kg/m2

Inclusion Criteria (Healthy controls):

• Intact spinal cord
• Matched on gender, age and BMI to the group with spinal cord injury

Exclusion Criteria:

• Treatment with antidiabetics
• Treatment with anti-resorptive agents
• Gastrointestinal disease
• Smoking
• Long term steroid treatment
• Weight change more than 3 kg within the last 3 months.
• Overweight or intestinal surgery