Gut Peptides and Bone Remodeling in Children With Neuromuscular Disorders

Gut Peptides and Bone Remodeling in Children With Neuromuscular Disorders

Both GIP and GLP-2 reduce bone resorption (measured as CTX) in healthy adult individuals. In this study, we will investigate whether GIP and GLP-2 reduce CTX in children with spinal muscular atrophy, duchenne muscular dystrophy, or cerebral palsy.

Inclusion Criteria:

- Diagnosis with Cerebral palsy (CP), Duchenne muscular dystrophy (DMD) or Spinal muscular atrophy (SMA) resulting in the need of a wheelchair

Exclusion Criteria:

• Use of anti-resorptive medication
• Confounding illnesses
• Pregnancy
• Allergy towards the components given on the test days
• Hgb<6.5 mmol/L