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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
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Hypoparathyroidism (hypoPT) is characterized by low levels of PTH.
In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liquid meal (Nutridrink) | Experimental | Liquid meal (Nutridrink) |
|
| GIP | Experimental | Glucose-dependent insulinotropic polypeptide |
|
| GLP-2 | Experimental | Glucagon-like peptide-2 |
|
| Placebo (saline) | Experimental | Placebo (saline) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liquid meal (Nutridrink) | Other | Liquid meal ingested over 1 minute. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Serum concentration of C-terminal telopeptide (CTX) | Marker of bone resorption, measured in serum | -10 to 240 minutes |
| N-terminal propeptide of type 1 procollagen (P1NP) | Marker of bone formation, concentration measured in serum | -10 to 240 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| PTH | PTH concentration measured in serum | -10 to 240 minutes |
| Glucose-dependent insulinotropic polypeptide (GIP) | Gut hormone, concentration measured in plasma |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Blood pressure (systolic and diastolic) measured before blood sampling | -10 to 240 minutes |
| Heart rate | Heart rate measured before blood sampling |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mette Rosenkilde, MD | University of Copenhagen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | 2650 | Denmark |
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| ID | Term |
|---|---|
| D007011 | Hypoparathyroidism |
| D001862 | Bone Resorption |
| D019294 | Xanthomatosis, Cerebrotendinous |
| ID | Term |
|---|---|
| D010279 | Parathyroid Diseases |
| D004700 | Endocrine System Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| GIP |
| Other |
Subcutaneous injected GIP |
|
| GLP-2 | Other | Subcutaneous injected GLP-2 |
|
| Placebo (saline) | Other | Subcutaneous injected Placebo (saline) |
|
| -10 to 240 minutes |
| Glucagon-like peptide-2 (GLP-2) | Gut hormone, concentration measured in plasma | -10 to 240 minutes |
| Glucagon-like peptide-1 (GLP-1) | Gut hormone, concentration measured in plasma | -10 to 240 minutes |
| Glucose | Glucose concentration measured in serum | -10 to 240 minutes |
| Insulin | Insulin concentration measured in serum | -10 to 240 minutes |
| C-peptide | C-peptide concentration measured in serum | -10 to 240 minutes |
| -10 to 240 minutes |
| D008052 |
| Lipid Metabolism, Inborn Errors |
| D008661 | Metabolism, Inborn Errors |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D014973 | Xanthomatosis |
| D017670 |
| Sodium Compounds |